The availability of Antifungal Drugs are relatively few because the eukaryotic pathogens have many of the same structure and metabolic pathways as human cells, so there are few target selective toxicity. Antifungal Drugs ranges from the relatively nontoxic drug used to treat superficial skin infections to the highly toxic reserved for treating life threatening Systemic Infections.
Griseofulvin produced by a species of penicillin, is used to treat infections caused by skin fungi(dermatophytes), the fungi that invades keratin containing structure such as skin and nails. It is taken orally simply because it can be absorbed from the intestinal tract and concentrated in the dead keratitis ed layers of the skin. There, Griseofulvin is taken up by the invading fungi and inhibits their growth by interfering with cell division. Although the treatment takes many months.
A azoles are larger family of chemically synthesized drugs, some which are antifungal in thier activity. The antifungal above, including clotrimazole, ketoconazole, Mico napoleon, itraconazole and fluconazole act by interfering with synthesis of ergosterol
The azoles are wide spectrum antifungal Drugs.
Amphotericin B is the most important of the pollens antibiotics, all of which are produced by streptomytes.
Flucytosine is a synthetic derivatives of cytosine, a natural primitive found in nucleic acids. Enzymes within fungal cells convert Flucytosine to 5_ flucorouracil, which inhibits an enzymes required for nucleic acid synthesis.
Fluconazole is another antifungal drug that is used to treat fungal infections caused by Candida, Cryptococcus, and Pneumocystis species.
Voriconazole is an antifungal drug that is used to treat fungal infections caused by Aspergillus, Candida, and Scedosporium species.